Located just 2.5 miles apart, this marks the 23rd meeting between these two city rivals, with the Pride holding a 14-9 all time advantage.
Springfield, which was ranked 15th in the latest USILA National Coaches Poll, last hosted an NCAA game in 2010 when it defeated Widener, 7-1, in a first round contest.
The Pride, which is making its seventh-straight trip to the NCAA Championship, captured the New England Women's and Men's Athletic Conference Championship on Saturday after doubling up Babson, 12-6.
This season, Springfield has a 14-3 record, marking just the third time in the past 14 seasons that Springfield has reached the 14-win plateau. Western New England owns a 10-7 record and reached the NCAA Championship after knocking off Endicott in the CCC Tournament.
The winner of the Springfield/Western New England game will advance and travel to take on Cortland on Saturday, May 10.
Earlier this season, the Pride poured in five fourth-quarter goals to rally for a 9-7 victory over cross-town rival Western New England on Saturday afternoon in front of 1,500 fans at Stagg Field on March 8. It marked the third-straight season that Springfield has been the victor over the Golden Bears in this cross-town showdown.